Trimodal organ‑preserving treatment of muscle‑invasive bladder cancer

Purpose of the study . Generalization world experience organ‑preserving treatment in muscle‑invasive bladder cancer Materials and methods The literature was searched Medline, Cochrane Library, Elibrary PubMed systems. Publications describing modern possibilities were included, 58 which used to write this review. Results review highlights results international randomized significant non‑randomized studies cancer. Special attention is paid description a combination achieve its maximum effectiveness while maintaining quality life patients. analysis carried out, confirming prospects with careful selection Conclusion Organ-preserving trimodal therapy for remains an alternative strategy. Careful patients plays key role. approach (TMT) as follows: complete transurethral resection (TURB), neoadjuvant or adjuvant chemotherapy, subsequent assessment response (re‑staging TURB) should be performed; pathomorphological response, course remote radiation up TFD 60–66 Gy case traditional fractionation (focal use hypofractionation modes are also possible), using irradiation technologies (IGRT, IMRT). In incomplete implementation radical cystectomy (RCE) shown. If relapse occurs during follow‑up after volume TMT, life‑saving RCE above conditions met, oncological TMT equivalent those RCE, but require further study.